This course consists of two main parts:  fundamental engineering technologies and methodologies,  and their clinical applications. In the first part students learn different engineering techniques and methods including mathematical modeling and simulation of a dynamic system, design methodology, geometric optics, kinematics, and statistics.  In the second part students learn how these techniques or methods are applied in medical field.  Case studies focus on specific organs such as eye, ear, and lung. In each study three aspects are covered: physiological, clinical, and instrumentation aspects. These 2 parts emphasize on the activities in the Medical Instrumentation.